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zofenopril + nebivolol
- Development stage
- Unknown
- Lead developer
- Menarini
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Zofenopril + nebivolol is a combination therapy used primarily for the treatment of hypertension and heart failure. Zofenopril is an angiotensin-converting enzyme (ACE) inhibitor that lowers blood pressure by inhibiting the conversion of angiotensin I to angiotensin II, leading to vasodilation and reduced aldosterone secretion. Nebivolol is a highly selective beta-1 adrenergic receptor antagonist (beta-blocker) with additional beta-3 agonist activity that stimulates endothelial nitric oxide synthase, resulting in increased nitric oxide production and further vasodilation. Both drugs have antioxidant and cardioprotective properties. The combination has been studied in clinical trials for its effectiveness in patients whose blood pressure remains uncontrolled on monotherapy[2][4][5][8].
- Other names
- nebivolol + zofenopril
02
Targets
ADRB3 (β3)ACE (Angiotensin Converting Enzyme)ADRB1 (β1)ADRB2 (β2)
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