Target intelligence / Profile preview

1,3-beta-D-glucan synthase

Molecular classification: Enzyme, Glycosyltransferase

Overview

1,3-beta-D-glucan synthase is a membrane-bound glucosyltransferase enzyme complex that catalyzes the synthesis of (1→3)-β-D-glucan, a major structural polysaccharide in the fungal cell wall. This enzyme is essential for fungal cell wall integrity and viability and serves as a key pharmacological target for antifungal drugs. Inhibitors cause loss of structural integrity in pathogenic fungi, leading to osmotic instability and death of susceptible cells.

Other names: GS-IIparamylon synthetasecallose synthase

Mechanism of action

Inhibition of beta-(1,3)-D-glucan synthesis, leading to cell wall disruption and fungal cell death.

Biological functions

Cell wall synthesisFungal cell wall integrityCell division septum formationAscospore wall assembly

Disease associations

Infection

Safety considerations

Compromised cell wall integrity leading to cell cycle arrestPotential for resistance development

Interacting drugs

Caspofungin

3 more in the full profile.

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