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2',5'-Oligoadenylate Synthetase (OAS)

Target: OAS
Molecular classification: Enzyme

Overview

2',5'-Oligoadenylate synthetase (OAS) is a family of enzymes that play a central role in the innate immune response to viral infection. Upon detection of dsRNA, OAS enzymes catalyze the conversion of ATP into 2',5'-linked oligomers of adenosine (2-5A), activating RNase L and leading to RNA degradation. There are multiple isoforms of OAS enzymes. OAS proteins are also involved in other cellular processes such as apoptosis and growth control.

Other names: 2-5A Synthetase

Mechanism of action

Activation of RNase L, leading to RNA degradation

Biological functions

Antiviral defenseImmune responseApoptosisGrowth control

Disease associations

InfectionAutoinflammatory immunodeficiency syndromes

Safety considerations

Excessive RNA degradationImmune activation

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