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2,3-Diphosphoglycerate Synthesis Pathway (2,3-DPG Synthesis Pathway)
- Target
- 2,3-DPG Synthesis Pathway
- Molecular classification
- Metabolic Pathway, Glycolysis, Enzyme-regulated pathway
01
Overview
The 2,3-Diphosphoglycerate (2,3-DPG) synthesis pathway, also known as the Luebering-Rapoport shunt, is a metabolic pathway within red blood cells that regulates hemoglobin's affinity for oxygen. It involves the conversion of 1,3-bisphosphoglycerate to 2,3-BPG by bisphosphoglycerate mutase and the subsequent hydrolysis of 2,3-BPG to 3-phosphoglycerate by bisphosphoglycerate phosphatase. This pathway is crucial for adapting to hypoxic conditions and ensuring efficient oxygen delivery to tissues.
- Other names
- 2,3-Bisphosphoglycerate Synthesis PathwayLuebering-Rapoport Shunt2,3-BPG Synthesis Pathway
02
Mechanism of action
N/A
03
Biological functions
Regulation of oxygen affinity of hemoglobinModulation of oxygen release in red blood cellsRed blood cell metabolism
04
Disease associations
AnemiaHypoxiaErythrocyte disorders
05
Biomarkers
2,3-DPG levels in red blood cells
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