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Target intelligence / Profile preview
2,3-Oxidosqualene Cyclase (OSC)
- Target
- OSC
- Molecular classification
- Enzyme, Isomerase, Oxidosqualene mutase/cyclase
01
Overview
2,3-Oxidosqualene cyclase (OSC) is a key enzyme in the biosynthesis of sterols and triterpenes. It catalyzes the cyclization of 2,3-oxidosqualene into various polycyclic products such as lanosterol and cycloartenol, which are precursors for cholesterol and other sterols in animals, fungi, and plants. OSC's activity represents a crucial step in the formation of the steroid nucleus. Inhibitors targeting OSC are being explored for hypocholesterolemic effects as well as antifungal or phytotoxic applications.
- Other names
- Lanosterol synthaseOxidosqualene cyclaseCycloartenol synthaseLupeol synthaseBeta-amyrin synthase
02
Mechanism of action
Inhibition of 2,3-oxidosqualene cyclization
03
Biological functions
Sterol biosynthesisTriterpene biosynthesisLipid metabolism regulation
04
Disease associations
Disorders related to cholesterol metabolismLiver injury under intermittent hypoxiaHypercholesterolemiaFungal infections
05
Interacting drugs
Ro 48-8071
1 more in the full profile.
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