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Target intelligence / Profile preview
Bacterial Ribosome 50S Subunit 23S rRNA (23S rRNA)
- Target
- 23S rRNA
- Molecular classification
- Ribosomal RNA, RNA, Non-coding RNA
01
Overview
The 23S rRNA is a critical component of the bacterial 50S ribosomal subunit and essential for protein synthesis. It forms the structural and functional core of the subunit, catalyzing peptide bond formation at the peptidyl transferase center. Many antibiotics target this region, and resistance often arises from mutations or modifications within the 23S rRNA.
- Other names
- 23S ribosomal RNA50S Ribosomal Subunit RNA
02
Mechanism of action
Inhibition of protein synthesis via binding to the peptidyl transferase center and/or tRNA binding sites of the 23S rRNA, disrupting peptide bond formation.
03
Biological functions
Peptidyl transferase activitytRNA bindingProtein synthesisTranslation elongation
04
Disease associations
Infection
05
Safety considerations
Antibiotic resistance development due to mutations or methylation of key residues within 23S rRNA.
06
Interacting drugs
Erythromycin
5 more in the full profile.
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