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26S Proteasome (β5-Subunit) (None)
- Target
- None
- Molecular classification
- Enzyme, Protease, Peptidase, Proteasome subunit
01
Overview
The β5 subunit of the 26S proteasome is a key component of the ubiquitin-proteasome system (UPS), responsible for the chymotrypsin-like proteolytic activity within the 20S core particle. It plays a crucial role in degrading ubiquitinated proteins, maintaining cellular protein homeostasis, and regulating various cellular processes. Inhibition of β5 is a therapeutic strategy in cancer treatment.
- Other names
- PSMB5Proteasome subunit beta type-5Chymotrypsin-like activity of the proteasome
02
Mechanism of action
Reversible inhibition of the chymotrypsin-like activity of the β5 subunit of the 20S proteasome core particle
03
Biological functions
Protein quality controlRegulated protein degradationUbiquitin-proteasome systemCell cycle regulationSignal transductionStress response
04
Disease associations
CancerNeurodegenerative disease (indirectly, through protein misfolding)Inflammation (indirectly, through NF-κB regulation)Other (proteinopathies)
05
Safety considerations
Peripheral neuropathy (associated with proteasome inhibitors)Thrombocytopenia (associated with proteasome inhibitors)
06
Interacting drugs
Ixazomib
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