28S ribosomal protein S24, mitochondrial (MRPS24)

28S ribosomal protein S24, mitochondrial (MRPS24) is a nuclear-encoded mitochondrial ribosomal protein that forms part of the small 28S subunit of the mammalian mitochondrial ribosome (mitoribosome)[2][4][7]. It is essential for protein synthesis within the mitochondria, contributing to mitochondrial translation of thirteen membrane proteins required for oxidative phosphorylation[2][3][5]. MRPS24 is structurally related to bacterial ribosomal protein S3 and functions as part of a central cluster in the mitoribosomal small subunit, interacting with other ribosomal proteins in the head region and participating in mRNA recruitment and decoding during mitochondrial translation[3]. Expression of MRPS24 is upregulated in lung adenocarcinoma and is correlated with poor prognosis, tumorigenesis, immune cell infiltration, methylation status, and genetic alterations, suggesting a role as a biomarker for immune-related microenvironment and cancer prognosis[1]. MRPS24 is essential during embryogenesis, with loss-of-function causing lethality, and is not functionally redundant with other mitochondrial ribosomal proteins[5]. No interacting drugs, known mechanisms of drug action, or safety concerns have been established for MRPS24.

Other names

Mitochondrial ribosomal protein S24Small ribosomal subunit protein uS3mHSPC335MRP-S24S24mtbMRP4728S ribosomal protein S24, mitochondrialbMRP-47