28S ribosomal protein S33, mitochondrial (MRPS33)

28S ribosomal protein S33, mitochondrial (MRPS33) is a protein encoded by the nuclear gene MRPS33 and functions as a structural component of the small (28S) subunit of the mitochondrial ribosome (mitoribosome) in mammals. It is essential for mitochondrial protein synthesis, facilitating translation initiation and maintaining the structural and functional integrity of the mitoribosome. This protein is highly conserved across mammalian species, with no functional redundancy; loss of function is often lethal due to disruption of mitochondrial translation. MRPS33 is not considered a typical therapeutic drug target, nor are there specific drugs or agents that interact with it directly. Disease association is limited, though it is linked in gene databases to rare disorders affecting mitochondrial oxidative phosphorylation. There are no established biomarkers or safety concerns directly related to MRPS33. MRPS33 is a mitochondrial ribosomal protein; not a therapeutic target. Its main role is structural—essential for mitochondrial translation. Associated with rare mitochondrial disorders, but not directly targeted by drugs. Name and identity are correct; information is structurally complete for knowledge purposes.

Other names

MRPS33MRP-S33mitochondrial ribosomal protein S33Small ribosomal subunit protein mS33PTD003S33mtmS3328S ribosomal protein S33, mitochondrial