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Target intelligence / Profile preview
3',5'-cyclic-AMP phosphodiesterase 4B (PDE4B)
- Target
- PDE4B
- Molecular classification
- Enzyme, Phosphodiesterase
01
Overview
PDE4B (phosphodiesterase 4B) is an enzyme that hydrolyzes and inactivates cyclic adenosine monophosphate (cAMP), a key second messenger involved in regulating numerous physiological processes. It belongs to the type IV, cAMP-specific cyclic nucleotide phosphodiesterase family. PDE4B regulates cellular concentrations of cAMP, impacting signal transduction for hormones, neurotransmitters, and other extracellular signals. It is involved in various biological processes, including immune responses and CNS signaling. Altered activity is linked with various cancers and neuropsychiatric disorders. It is targeted by drugs like rolipram and crisaborole. Multiple splice variants exist.
02
Mechanism of action
Inhibition of PDE4B enzymatic activity leading to increased intracellular cAMP levels.
03
Biological functions
Signal transductionRegulation of cAMP levelsRegulation of cardiac muscle cell contractionLeukocyte migrationNeutrophil chemotaxis/homeostasisT cell receptor signaling pathway
04
Disease associations
CancerNeuropsychiatric disordersSchizophreniaBipolar disorderNeuroinflammation
05
Safety considerations
Potential for off-target effects due to interaction with other PDE4 subtypes.Potential for side effects associated with increased cAMP levels in various tissues.
06
Interacting drugs
Rolipram
1 more in the full profile.
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