Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
3',5'-cyclic-AMP phosphodiesterase 4A (PDE4A)
- Target
- PDE4A
- Molecular classification
- Enzyme, Phosphodiesterase
01
Overview
3',5'-cyclic-AMP phosphodiesterase 4A (PDE4A) is an enzyme that hydrolyzes the second messenger cyclic adenosine monophosphate (cAMP), a key regulator of numerous physiological processes. By breaking down cAMP, PDE4A plays a central role in modulating cellular responses to extracellular signals and maintaining cellular homeostasis. PDE4A is a therapeutic target, specifically isoforms 1, 2, 6, and 7, with inhibitors being explored or used for conditions like depression and chronic inflammatory diseases due to their ability to modulate immune cell function and neuronal signaling.
- Other names
- DPDE2PDE46cAMP-specific phosphodiesterase 4A
02
Mechanism of action
Inhibition of cAMP hydrolysis, leading to increased intracellular cAMP levels.
03
Biological functions
Hydrolyzes cAMP to AMPRegulation of cAMP levelsSignal transductionRegulation of immune cell functionRegulation of neuronal signaling
04
Disease associations
InflammationDepressionAnxietyOther
05
Interacting drugs
Rolipram
3 more in the full profile.
Beyond the preview
Go deeper on 3',5'-cyclic-AMP phosphodiesterase 4A (PDE4A).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on 3',5'-cyclic-AMP phosphodiesterase 4A (PDE4A).