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Target intelligence / Profile preview
3-beta-hydroxysteroid dehydrogenase (3β-HSD)
- Target
- 3β-HSD
- Molecular classification
- Enzyme, Oxidoreductase
01
Overview
3-beta-hydroxysteroid dehydrogenase (3β-HSD) is a crucial enzyme in steroid hormone biosynthesis. It catalyzes the oxidative conversion of Δ5-3β-hydroxysteroids to Δ4-3-ketosteroids, an essential step for producing all classes of active steroid hormones, including progesterone, glucocorticoids, mineralocorticoids, androgens, and estrogens. There are two main human isoforms: HSD3B1 (expressed mainly in placenta and peripheral tissues) and HSD3B2 (predominantly expressed in adrenal gland and gonads). Mutations in HSD3B2 cause congenital adrenal hyperplasia due to impaired steroidogenesis.
02
Mechanism of action
Inhibition of 3β-HSD activity, thereby blocking the production of steroid hormones such as progesterone, glucocorticoids, mineralocorticoids, androgens, and estrogens.
03
Biological functions
Steroid hormone biosynthesisConversion of Δ5-3β-hydroxysteroids to Δ4-3-ketosteroidsSteroid degradationRegulation of plasma hormone levels
04
Disease associations
Congenital adrenal hyperplasiaAdrenal insufficiencyDisrupted sexual development/maturation
05
Safety considerations
Potential for disrupting the balance of multiple steroid hormones.Side effects related to glucocorticoid and mineralocorticoid deficiency.Effects on sexual development and reproduction.
06
Biomarkers
Elevated ratios of precursor steroids (e.g., pregnenolone, 17α-hydroxypregnenolone, DHEA) due to blocked conversion steps
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