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Target intelligence / Profile preview
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP)
- Target
- EBP
- Molecular classification
- Enzyme, Isomerase
01
Overview
Delta 7,8-isomerase (EBP), also known as cholestenol delta-isomerase or 3β-hydroxysteroid-Δ8,Δ7-isomerase (EC 5.3.3.5), is an enzyme that catalyzes the isomerization of a double bond in sterol molecules from the Δ8 position to the Δ7 position within the B-ring of sterols. This reaction is a crucial step in cholesterol biosynthesis, converting Δ8(9)-sterols into their corresponding Δ7-isomers. The enzyme is localized to the endoplasmic reticulum membrane. Mutations in EBP are linked with X-linked chondrodysplasia punctata type II. Several drugs, including tamoxifen and clomiphene, can inhibit Delta 7,8-isomerase activity.
- Other names
- Delta 7,8-isomeraseCholestenol delta-isomeraseEmopamil binding proteinSI
02
Mechanism of action
Inhibition of Delta 7,8-isomerase activity, leading to disruption of sterol metabolism
03
Biological functions
Cholesterol biosynthetic processSteroid metabolic processIsomerization of Δ8-sterols to Δ7-sterols
04
Disease associations
X-linked chondrodysplasia punctata type II
05
Safety considerations
Potential side effects related to sterol metabolism disruption
06
Interacting drugs
Tamoxifen
1 more in the full profile.
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