Target intelligence / Profile preview

3-oxoacyl-[acyl-carrier-protein] reductase (FabG)

Target: FabG
Molecular classification: Enzyme, Oxidoreductase

Overview

3-oxoacyl-[acyl-carrier-protein] reductase (FabG) is an enzyme crucial for fatty acid biosynthesis in bacteria and plants. It catalyzes the NADPH-dependent reduction of 3-oxoacyl-[ACP] to (3R)-3-hydroxyacyl-[ACP], a key step in the elongation cycle of fatty acid synthesis. As it is essential for bacterial viability and absent from the human cytosolic type I FAS system, FabG is a promising target for antibiotic development.

Other names: beta-ketoacyl-(ACP) reductasebeta-ketoacyl thioester reductaseNADPH-specific 3-oxoacyl-[ACP]reductase

Mechanism of action

Inhibition of fatty acid biosynthesis

Biological functions

Fatty acid biosynthesisPolyunsaturated fatty acid biosynthesis

Disease associations

Infection

Safety considerations

Off-target effects in organisms with similar enzymesPotential for resistance development

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