3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial (OXSM)

3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial (OXSM) is an **enzyme** encoded by the *OXSM* gene, located on human chromosome 3[1][2][5]. It catalyzes a key step in the mitochondrial fatty acid synthesis pathway, required for the elongation of fatty acid chains in mitochondria and plays an essential role in the biosynthesis of lipoic acid—an important cofactor for mitochondrial metabolic enzymes[1][3]. OXSM thus supports mitochondrial energy metabolism and cell viability. While it is a critical metabolic enzyme, there are currently no known drugs that specifically target OXSM, nor are there established uses as a therapeutic target or biomarker in clinical practice[2][5]. **Summary of key properties:** - Protein type: Enzyme - Location: Mitochondrion - Main functions: Fatty acid elongation, lipoic acid biosynthesis - Canonical identifier: UniProt Q9NWU1, GeneCards OXSM, NCBI Gene 54995[2][5] OXSM should not be confused with FASN (fatty acid synthase), which catalyzes cytosolic fatty acid biosynthesis; OXSM specifically functions within the mitochondria[1][2].

Other names

Beta-ketoacyl-ACP synthasebeta-ketoacyl synthaseOXSMKSFASN2DFLJ20604CEM1KASI3-ketoacyl-acyl carrier protein synthase3-oxoacyl-acyl-carrier-protein synthaseacyl-malonyl acyl carrier protein-condensing enzymetype II mitochondrial beta-ketoacyl synthase

Inhibition of mitochondrial fatty acid synthesis (hypothetically, for future pharmacological targeting)