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Target intelligence / Profile preview
3-oxoacyl-[acyl-carrier-protein] synthase 3 (KAS III)
- Target
- KAS III
- Molecular classification
- Enzyme
01
Overview
3-oxoacyl-[acyl-carrier-protein] synthase 3 (KAS III, FabH) is an enzyme that catalyzes the initial condensation step in the type II fatty acid synthesis (FAS II) pathway in bacteria and plant plastids. It uses acetyl-CoA and malonyl-ACP to form acetoacetyl-ACP, initiating fatty acid biosynthesis. As it is essential for bacterial cell membrane formation but absent in mammals, it represents a promising target for novel antibiotics.
- Other names
- Beta-ketoacyl-[acyl-carrier-protein] synthase IIIFabHEcFabH
02
Mechanism of action
Inhibition of bacterial fatty acid synthesis
03
Biological functions
Fatty acid biosynthesisLipid metabolismQuorum sensing precursor synthesis
04
Disease associations
Infection
05
Safety considerations
Off-target effects on homologous eukaryotic enzymes (e.g., mitochondrial OXSM)
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