3-phosphoinositide dependent protein kinase 2, pseudogene (PDPK2P)

PDPK2P (3-phosphoinositide dependent protein kinase 2, pseudogene) is a non-protein coding gene/Pseudogene that gives rise to a long noncoding RNA, lncRNA-PDPK2P, which is highly homologous to the functional kinase PDK1 but does not encode an active enzyme[2][1]. The transcript of PDPK2P acts as a competitive endogenous RNA, regulating cell proliferation, apoptosis, migration, and invasion, particularly in hepatocellular carcinoma, by interacting with PDK1 and modulating the PDK1/AKT/caspase signaling cascade[1]. This pseudogene is not a conventional protein target and is not referenced in major drug-interaction databases. Its altered expression is clinically associated with tumor progression and poor prognosis, and it is of interest mainly as a disease biomarker or possible regulatory mechanism in cancer biology[1].

Other names

Putative 3-phosphoinositide-dependent protein kinase 2PDPK23-phosphoinositide-dependent protein kinase 2 pseudogene3-phosphoinositide dependent protein kinase-1 pseudogeneEC 2.7.11.1

None directly; lncRNA-PDPK2P regulates PDK1 function via RNA-RNA interaction and competitive endogenous RNA (ceRNA) mechanisms affecting the PDK1/AKT/caspase pathway