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30S Ribosomal Subunit (Prokaryotic) (30S)

Target: 30S
Molecular classification: Ribosomal subunit, RNA-protein complex

Overview

The 30S ribosomal subunit is the smaller component of the prokaryotic 70S ribosome, essential for protein synthesis in bacteria and archaea. It consists of 16S rRNA and approximately 21 proteins. Its primary functions include binding mRNA, ensuring accurate codon-anticodon pairing during decoding, and collaborating with the 50S subunit for translocation. It is a common target for antibacterial drugs.

Other names: Prokaryotic Small Ribosomal SubunitSmall Ribosomal Subunit (Prokaryotic)

Mechanism of action

Inhibition of prokaryotic protein synthesis by disrupting mRNA decoding, tRNA binding, or translocation.

Biological functions

mRNA bindingtRNA selectionDecoding mRNATranslation initiationProtein synthesis

Disease associations

Infection

Safety considerations

Potential for off-target effects on mitochondrial ribosomes (which are structurally similar to prokaryotic ribosomes).Development of antibiotic resistance.

Interacting drugs

Tetracycline

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