37 kDa laminin receptor precursor (RPSA) (RPSA)

The 37 kDa laminin receptor precursor (37LRP), also known as the immature laminin receptor or 37 kDa oncofetal antigen (OFA/iLRP), is a multifunctional protein encoded by the RPSA gene [1]. It exists in two main forms: a 37 kDa cytoplasmic precursor and a 67 kDa mature membrane-bound form (67LR), which acts as a high-affinity receptor for laminin in the extracellular matrix [2]. Beyond its role in cell adhesion and migration, the protein is an integral component of the 40S ribosomal subunit, where it facilitates protein synthesis and ribosome biogenesis [1]. In clinical oncology, this receptor is frequently overexpressed on the surface of various malignant cells, including breast, lung, and colon cancers, where it correlates with increased metastatic potential and poor patient prognosis [4]. It also serves as a critical entry receptor for several human pathogens, including the cellular prion protein (PrPc) and various viruses such as Dengue and Sindbis [3]. Therapeutic targeting of the receptor involves the use of monoclonal antibodies or small molecules like epigallocatechin gallate (EGCG) to inhibit its interaction with laminin or pathogens [4]. However, the ubiquitous nature of its ribosomal function presents a significant challenge for achieving high therapeutic selectivity [2].

Other names

37 kDa oncofetal antigenImmature laminin receptor protein67 kDa laminin receptorRibosomal protein SALAMR1LBPp40

Inhibition of laminin-receptor interaction and modulation of intracellular signaling pathways [2][4].