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39S ribosomal protein L10, mitochondrial (MRPL10)
- Target
- MRPL10
- Molecular classification
- Ribosomal protein, Structural constituent of ribosome, Mitochondrial protein, Other
01
Overview
39S ribosomal protein L10, mitochondrial (MRPL10) is a core structural protein of the large (39S) subunit of the mitochondrial ribosome. It is encoded by a nuclear gene, imported into mitochondria, and is essential for mitochondrial protein synthesis necessary for energy production and cellular metabolism. Beyond its structural role, MRPL10 participates in the regulation of reactive oxygen species (ROS) homeostasis and cellular redox balance, particularly in the context of cancer cells where it can modulate mitochondrial complex I activity and ATP production. While genetic variants have been linked to neurological disorders (e.g., autism spectrum disorder), MRPL10 itself is not typically considered a direct therapeutic target or receptor. Proper function of MRPL10 is vital for cell viability, and deficiencies lead to impaired mitochondrial function and cellular energy deficit.
- Other names
- MRPL10Large ribosomal subunit protein uL10mL10mtMRP-L10L8mtMRP-L8RPML8uL10m39S ribosomal protein L10, mitochondrial39S ribosomal protein L8, mitochondrialMGC17973
02
Mechanism of action
Null (no approved drugs targeting this molecule)
03
Biological functions
Mitochondrial protein synthesis (translation)RNA bindingRegulation of reactive oxygen species (ROS) homeostasisCellular energy metabolism
04
Disease associations
Autism spectrum disorderEpilepsy, myoclonic juvenilePancreatic cancer (ROS regulation, potential role in progression)Other (general role in diseases linked to mitochondrial dysfunction)
05
Safety considerations
No drug-interaction related safety concerns known; disruption of MRPL10 is lethal to cells, indicating critical importance for basic cellular function
06
Biomarkers
Altered MRPL10 levels may indicate mitochondrial dysfunction or cancer progression (particularly pancreatic cancer); also studied in autism
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