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39S ribosomal protein L24, mitochondrial (MRPL24)
- Target
- MRPL24
- Molecular classification
- Other, Ribosomal protein, Mitochondrial ribosomal protein, Structural constituent of ribosome
01
Overview
39S ribosomal protein L24, mitochondrial (MRPL24) is a structural protein encoded by the nuclear MRPL24 gene and is incorporated into the large (39S) subunit of the mitochondrial ribosome (mitoribosome) in humans. It participates in mitochondrial protein synthesis by contributing to the structure and function of mitoribosomes, which differ from prokaryotic ribosomes in protein-to-rRNA composition and lack of 5S rRNA. MRPL24 is larger than its E. coli counterpart and is essential for the translation of mitochondrial-encoded proteins that are critical for oxidative phosphorylation and other mitochondrial functions[1][2][3][7].
- Other names
- Large ribosomal subunit protein uL24mL24mtMRP-L24MRP-L18uL24m39S ribosomal protein L24mitochondrial large ribosomal subunit protein uL24m
02
Biological functions
Protein synthesisMitochondrial translationStructural constituent of ribosome
03
Disease associations
Other (reported associations include Dyskinetic cerebral palsy and Wolff-Parkinson-White syndrome, but not established as direct causative or common biomarker)
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