39S ribosomal protein L28, mitochondrial (MRPL28)

39S ribosomal protein L28, mitochondrial (MRPL28) is a nuclear-encoded protein that is a component of the mitochondrial ribosome large 39S subunit, where it plays a key structural and functional role in protein synthesis within the mitochondrion. MRPL28 primarily functions in mitochondrial translation as an RNA-binding component. In rare instances, a fragment of MRPL28 has been described as a melanoma antigen recognized by HLA-A24-restricted cytotoxic T-lymphocytes due to its association with tyrosinase in immune recognition contexts. There are limited known disease associations and no current evidence that MRPL28 is a direct drug target or has interacting small molecules. Key context and details: - MRPL28 is encoded on human chromosome 16 and is part of the set of proteins that assemble into the mitochondrial ribosome, distinct from cytosolic ribosomes. - It is broadly classified within mitochondrial ribosomal proteins, under structural proteins not typically considered as direct therapeutic targets, enzymes, or receptors. - Sequence variation in MRPL28 may contribute to rare diseases, but it is not commonly implicated in major disease pathways or used as a biomarker outside of rare immunological observations. - No drugs are known to act directly on MRPL28, and there are no standard mechanisms of action or safety issues for therapeutic intervention with this target.

Other names

Large ribosomal subunit protein bL28mMAAT1L28mtMRP-L28p15bL28mMelanoma antigen p15Melanoma-associated antigen recognized by T-lymphocytesmelanoma-associated antigen recognized by cytotoxic T lymphocytes