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39S ribosomal protein L55, mitochondrial (MRPL55)
- Target
- MRPL55
- Molecular classification
- Mitochondrial ribosomal protein, Structural constituent of ribosome
01
Overview
39S ribosomal protein L55, mitochondrial (MRPL55) is a nuclear-encoded component of the large 39S subunit of the mammalian mitochondrial ribosome (mitoribosome)[1][3][6][7]. This protein helps facilitate translation of mitochondrial-encoded proteins necessary for mitochondrial function and energy production. Mammalian mitoribosomes are distinctly different from their prokaryotic counterparts in protein:rRNA ratio and protein sequence composition[3][6]. MRPL55 is not used as a therapeutic target, nor is it a receptor, channel, or enzyme; its main biological role is structural, enabling mitochondrial translation[1][3][6][7].
- Other names
- Large ribosomal subunit protein mL55MRPL55UNQ5835/PRO19675L55mtMRP-L55bL31m39S ribosomal protein L55, mitochondrialMitochondrial large ribosomal subunit protein bL31mAAVG5835L55ntPRO19675RM55_HUMAN
02
Mechanism of action
Not applicable; no drugs known to target this protein directly
03
Biological functions
Mitochondrial protein synthesisStructural component of the mitoribosomeTranslation within mitochondria
04
Disease associations
Has gene-disease associations noted, but no direct implication as a disease driver; involved in various mitochondrial disorders through indirect gene variants or expression changesVarious expression/disease associations reported in datasets, but not a direct target for disease therapy
05
Safety considerations
None reported; as a structural ribosomal protein, direct targeting could affect mitochondrial function systemically
06
Biomarkers
Some studies may include MRPL55 in gene expression signatures for tissues/diseases, but it is not a canonical biomarker for therapy or patient selection
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