4'-phosphopantetheinyl transferase PptT (PptT)

4'-phosphopantetheinyl transferase PptT is an essential enzyme in Mycobacterium tuberculosis that catalyzes the post-translational modification of various acyl carrier proteins (ACPs). It functions by transferring a 4'-phosphopantetheine moiety from coenzyme A to a conserved serine residue on target proteins, a process required to convert inactive apo-enzymes into their active holo-forms. This modification is critical for the activity of polyketide synthases and non-ribosomal peptide synthetases involved in the biosynthesis of mycolic acids, virulence-associated lipids, and the siderophore mycobactin. Because PptT is required for both the growth and persistence of the bacteria within the host, it is a highly validated therapeutic target for the treatment of tuberculosis. Small molecule inhibitors targeting PptT have shown potent bactericidal activity against both drug-sensitive and multidrug-resistant strains of M. tuberculosis by disrupting essential cell wall synthesis and nutrient acquisition pathways.

Other names

PptTRv2794c4'-phosphopantetheinyl transferaseSfp-type PPTase