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Target intelligence / Profile preview
5'-AMP-activated protein kinase subunit gamma-1 (PRKAG1)
- Target
- PRKAG1
- Molecular classification
- Enzyme subunit, Regulatory subunit
01
Overview
The AMP-activated protein kinase gamma 1 subunit (PRKAG1) is a regulatory component of the AMPK complex, a central energy sensor and regulator of cellular metabolism. It senses intracellular levels of AMP/ADP versus ATP, promoting activation of the catalytic α-subunit when energy is low. This leads to phosphorylation events that inhibit anabolic processes and stimulate catabolic pathways. PRKAG1 is crucial for metformin-mediated suppression of hepatic glucose production and is implicated in metabolic diseases.
- Other names
- AMPK gamma 1 subunitAMPK subunit gamma-1
02
Mechanism of action
Metformin-mediated suppression of hepatic glucose production via AMPK activation.
03
Biological functions
Energy sensingRegulation of cellular metabolismAllosteric regulation of AMPK activityRegulation of glycolysisRegulation of fatty acid oxidationRegulation of lipid biosynthesis
04
Disease associations
Metabolic disordersHeart diseaseObesityDiabetes mellitus type II
05
Safety considerations
Potential for dysregulation impacting whole-body metabolic regulation.
06
Interacting drugs
Metformin
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