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Target intelligence / Profile preview
Adenosine monophosphate activated protein kinase gamma 3 (AMPK γ3)
- Target
- AMPK γ3
- Molecular classification
- Enzyme, Protein kinase subunit, Regulatory subunit
01
Overview
Adenosine monophosphate activated protein kinase gamma 3 (AMPK γ3) is a non-catalytic regulatory subunit of the AMP-activated protein kinase (AMPK) complex, encoded by the PRKAG3 gene. AMPK is a heterotrimeric enzyme that acts as an energy sensor. The γ3 isoform is predominantly expressed in skeletal muscle and plays a key role in regulating muscle energy metabolism. Mutations in PRKAG3 are linked to altered insulin sensitivity and glycogen storage. AMPKγ3 is a therapeutic target for metabolic disorders such as type 2 diabetes.
- Other names
- 5'-AMP-activated protein kinase subunit gamma-3PRKAG3
02
Mechanism of action
Activation of AMPK, stimulation of glucose uptake via GLUT4 translocation, enhancement of fatty acid oxidation, inhibition of cholesterol synthesis, suppression of gluconeogenesis, inhibition of mTORC1 signaling
03
Biological functions
Energy sensingRegulation of glucose metabolismRegulation of fatty acid metabolismRegulation of glycogen storage
04
Disease associations
Type 2 Diabetes MellitusInsulin resistanceMetabolic disorders
05
Interacting drugs
AICAR
2 more in the full profile.
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