Target intelligence / Profile preview

5'-Ecto-nucleotidase (CD73)

Target: CD73
Molecular classification: Enzyme, Ectoenzyme

Overview

5'-Ecto-nucleotidase, commonly known as CD73, is a glycosylphosphatidylinositol (GPI)-anchored cell surface enzyme encoded by the NT5E gene. It catalyzes the dephosphorylation of extracellular adenosine monophosphate (AMP) to adenosine, playing a crucial role in purine salvage pathways and immunomodulation. CD73 is overexpressed in several solid tumors, contributing to an immunosuppressive tumor microenvironment.

Other names: ecto‑5′‑nucleotidaseNT5EEC 3.1.3.5

Mechanism of action

Inhibition of enzymatic activity to reduce adenosine production

Biological functions

Purinergic signalingImmunomodulationDephosphorylationCell adhesionSignal transduction

Disease associations

CancerInflammationHypoxia

Biomarkers

Soluble CD73

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