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Target intelligence / Profile preview
Steroid 5 alpha-reductase (5α-reductase)
- Target
- 5α-reductase
- Molecular classification
- Enzyme
01
Overview
Steroid 5 alpha-reductase is a family of membrane-bound enzymes that catalyze the irreversible reduction of the Δ4,5 double bond in Δ4-3-ketosteroids, converting testosterone into dihydrotestosterone (DHT). There are three main isozymes: Type 1 (SRD5A1), Type 2 (SRD5A2), and Type 3 (SRD5A3). Type 2 is especially important for male sexual development. Inhibitors like finasteride and dutasteride are used for BPH, androgenetic alopecia, and sometimes prostate cancer. Mutations can cause disorders of sex development.
- Other names
- 3-oxo-5α-steroid 4-dehydrogenase
02
Mechanism of action
Inhibition of steroid 5 alpha-reductase activity, reducing DHT levels
03
Biological functions
Steroid metabolismConversion of testosterone to dihydrotestosteroneBile acid biosynthesisNeurosteroid metabolism
04
Disease associations
Disorders of sex developmentBenign prostatic hyperplasia (BPH)Androgenetic alopecia (male pattern baldness)Prostate cancer
05
Safety considerations
Sexual dysfunctionDepressionProstate cancer risk
06
Interacting drugs
Finasteride
1 more in the full profile.
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