5'-Hydroxyasperentin

5'-Hydroxyasperentin is a secondary metabolite of the isocoumarin class, primarily produced by various fungal species such as Aspergillus flavus, Aspergillus tamarii, and Cladosporium cladosporioides. It is a hydroxylated derivative of asperentin, which is also known as cladosporin. Asperentin and its analogs are recognized for their potent biological activities, particularly as antifungal and antimalarial agents. They exert these effects by acting as highly selective inhibitors of the enzyme lysyl-tRNA synthetase (KRS), which is essential for protein synthesis; cladosporin is noted for its ability to inhibit Plasmodium falciparum KRS while showing minimal activity against the human version of the enzyme. The specific term "Production of 5'-hydroxyasperentin" refers to a biosynthetic process or an experimental measurement of the metabolite's synthesis rather than a defined therapeutic target molecule in humans.

Other names

5'-HydroxycladosporinAsperentin 5'-hydroxy derivative

Inhibition of lysyl-tRNA synthetase (KRS)