Gosset 5-alpha-reductase type II enzyme Overview
The 5-alpha-reductase type II enzyme, encoded by the SRD5A2 gene, is a membrane-bound oxidoreductase that catalyzes the irreversible conversion of testosterone to dihydrotestosterone (DHT), a more potent androgen. This reaction is NADPH-dependent and plays a critical role in male sexual development, particularly in the formation of external genitalia before birth. Mutations or deficiencies in SRD5A2 cause disorders of sex development (DSDs) such as ambiguous or atypical male genitalia due to insufficient DHT production during fetal life. Finasteride is a selective inhibitor used clinically for benign prostatic hyperplasia and androgenetic alopecia by blocking this enzyme's activity.
Mechanism of Action
Selective inhibitor of 5-alpha-reductase type II enzyme activity.
Biological Functions
Disease Associations
Safety Considerations
No safety concerns listed