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Target intelligence / Profile preview
5-alpha-reductase type II enzyme (SRD5A2)
- Target
- SRD5A2
- Molecular classification
- Enzyme, Oxidoreductase
01
Overview
The 5-alpha-reductase type II enzyme, encoded by the SRD5A2 gene, is a membrane-bound oxidoreductase that catalyzes the irreversible conversion of testosterone to dihydrotestosterone (DHT), a more potent androgen. This reaction is NADPH-dependent and plays a critical role in male sexual development, particularly in the formation of external genitalia before birth. Mutations or deficiencies in SRD5A2 cause disorders of sex development (DSDs) such as ambiguous or atypical male genitalia due to insufficient DHT production during fetal life. Finasteride is a selective inhibitor used clinically for benign prostatic hyperplasia and androgenetic alopecia by blocking this enzyme's activity.
- Other names
- Steroid 5 alpha-reductase type II3-Oxo-steroid delta(4)-dehydrogenase alpha polypeptide IISteroid delta(4)-3-one--delta(4)-reductase
02
Mechanism of action
Selective inhibitor of 5-alpha-reductase type II enzyme activity.
03
Biological functions
Testosterone to DHT conversionAndrogen biosynthesisSteroid metabolism
04
Disease associations
Disorders of sex development (DSDs)Benign prostatic hyperplasiaAndrogenetic alopeciaProstate cancer
05
Interacting drugs
Finasteride
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