Target intelligence / Profile preview

5-fluoro-2'-deoxyuridine-5'-monophosphate (FdUMP)

Target: FdUMP
Molecular classification: Nucleotide analog, Antimetabolite

Overview

FdUMP is an active metabolite of fluoropyrimidine drugs like 5-FU, acting as a potent inhibitor of thymidylate synthase (TS). It disrupts DNA synthesis by depleting dTMP pools, leading to cytotoxicity, especially in rapidly dividing cells. Its activity is modulated by intracellular folate levels.

Other names: 5-fluorodeoxyuridylate5-FdUMP2'-deoxy-5-fluoro-uridine 5'-monophosphate

Mechanism of action

Suicide inhibition of thymidylate synthase (TS)

Biological functions

Inhibition of DNA synthesisInduction of cell death

Disease associations

Cancer

Safety considerations

CytotoxicityDependence on folate levels

Interacting drugs

5-fluorouracil (5-FU)

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