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Target intelligence / Profile preview
5-hydroxytryptamine (serotonin) receptor 1F (5-HT1F)
- Target
- 5-HT1F
- Molecular classification
- G protein-coupled receptor, Receptor, GPCR, 5-HT₁ subfamily
01
Overview
The Serotonin Receptor 1F (5-HT1F) is a G protein-coupled receptor that belongs to the serotonin receptor family. It primarily couples to Gαi/o proteins, inhibiting adenylyl cyclase activity. It's implicated in neuronal regulation, neuroprotection, cell survival, modulation of pain pathways, and CNS disorders like migraine and depression. Lasmiditan is a selective agonist used for acute migraine treatment.
- Other names
- HTR1F5-HT-1FMR77HTR1EL[2]
02
Mechanism of action
Agonists inhibit adenylyl cyclase activity, leading to decreased cAMP levels.
03
Biological functions
Neuronal regulationNeuroprotectionCell survivalModulation of pain pathwaysInhibition of adenylyl cyclase activity
04
Disease associations
MigraineDepressionCentral nervous system disorders
05
Interacting drugs
Lasmiditan
6 more in the full profile.
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