5-hydroxytryptamine receptor 1 (5-HT1 receptor) (5-HT1 receptor)

The **5-hydroxytryptamine receptor 1 (5-HT1 receptor) family** comprises a group of G protein-coupled receptors that mediate the inhibitory actions of serotonin (5-HT) in the central and peripheral nervous systems by coupling primarily to Gi/o proteins, thereby inhibiting adenylyl cyclase and decreasing cAMP levels. Individual family members — including 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F — have distinct expression patterns and functional roles in modulating behavior, sensation, cognition, and vascular tone, and are targeted by various psychiatric and antimigraine drugs. "Serotonin receptor 1" should be clarified to a specific subtype for more precise discussion.

Other names

Serotonin receptor 15-HT15-HT1 receptor family5-hydroxytryptamine receptor 1 familyHTR1 (gene family)

Agonists: Activate Gi/o protein-coupled pathways, leading to inhibition of adenylyl cyclase activity, reducing cyclic AMP (cAMP) production, and causing neuronal hyperpolarization (opening of K+ channels by 5-HT1A, for example). Antagonists: Block receptor-mediated inhibition, can modulate neurotransmitter release.