5-hydroxytryptamine receptor 5B, pseudogene (HTR5BP)

5-hydroxytryptamine receptor 5B, pseudogene (HTR5BP) is a non-functional pseudogene in humans that is homologous to the functional 5-HT5B serotonin receptor present in rodents[7][8]. In rodents, the 5-HT5B receptor is a G protein-coupled receptor (GPCR) involved in serotonin signal transduction in the brain, primarily expressed in the habenula, hippocampus, and inferior olive[7]. However, in humans, the HTR5BP gene contains stop codons that prevent the expression of a functional protein, so it does not act as a drug target or have biological activity[7][8][9][3]. The term “receptor” is retained in its historical and orthologous context but does not denote a therapeutic or biological target in humans. **Summary of correct usage:** - HTR5BP is not a functional receptor or a drug target in humans; it is a pseudogene. All references to receptor function or pharmacology apply only to the orthologous, functional gene in rodents[7][8][9].

Other names

5-HT5BG protein-coupled receptor 134GPR134HTR5B5-hydroxytryptamine (serotonin) receptor 5 pseudogene5-hydroxytryptamine (serotonin) receptor 5A pseudogene5-hydroxytryptamine (serotonin) receptor 5B, pseudogene

null for human pseudogene