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50S Ribosomal Subunit (Bacterial) (50S Ribosomal Subunit)

Target: 50S Ribosomal Subunit
Molecular classification: Ribonucleoprotein, Ribosome

Overview

The 50S ribosomal subunit is the larger component of the prokaryotic (bacterial and archaeal) 70S ribosome, essential for protein synthesis. It consists of 23S rRNA, 5S rRNA, and over thirty distinct proteins. Its primary role is to catalyze translation, specifically peptide bond formation, and it is a common target for antibiotics.

Other names: Large Ribosomal SubunitProkaryotic 50S RibosomeBacterial 50S Ribosome

Mechanism of action

Inhibition of peptide bond formation or blocking nascent polypeptide exit channels.

Biological functions

Protein SynthesisTranslationPeptide Bond FormationtRNA BindingTranslocation

Disease associations

Infection

Safety considerations

Antibiotic resistance due to mutations in rRNA or ribosomal proteins

Interacting drugs

Erythromycin

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