5T4 Antigen (Trophoblast Glycoprotein) (None)

The 5T4 antigen (TPBG) is an oncofetal cell surface glycoprotein overexpressed across multiple solid tumors, including colorectal, ovarian, and gastric cancers. It is rarely found in healthy adult tissue, with limited expression during development or in certain neuronal subtypes. Its role includes promoting tumor progression through effects on cell movement and signaling pathways like Wnt. This makes it an attractive target for diverse anti-cancer therapies including vaccines, antibody-drug conjugates, superantigen-based approaches, and CAR-T cells. Clinical trials are ongoing to evaluate the efficacy and safety of these immunotherapeutic strategies.

Other names

TPBGWAIF1Trophoblast glycoproteinM6P1

Target of cancer vaccines, antibody-drug conjugates, tumor-targeted superantigens, and CAR-T cell therapies, aiming to eliminate 5T4-expressing tumor cells.