7SL RNA, cytoplasmic 698, pseudogene (RN7SL698P)

"7SL RNA, cytoplasmic 698, pseudogene" (RN7SL698P) is a processed pseudogene derived from the 7SL RNA sequence, which in its functional form is a critical non-coding RNA component of the signal recognition particle (SRP) involved in protein targeting to the endoplasmic reticulum[1][3][5]. Pseudogenes like RN7SL698P are defective, usually non-expressed, and do not encode functional RNA or protein; they are considered genomic remnants of evolutionary origin[3][5]. The vast majority of 7SL-derived loci in the human genome are pseudogenes resulting from reverse transcription and insertion events[3][5]. While most have no direct function, some pseudogenes may be transcribed and, in rare cases, play regulatory roles (e.g., acting as microRNA sponges), but this is not a generalizable or therapeutically targetable feature for 7SL pseudogenes as a class[2]. Key context and reasoning: - This entry refers specifically to a cytoplasmic 7SL pseudogene, not the canonical 7SL RNA itself (which is functionally and structurally important in the SRP)[1][4]. - Pseudogenes, including RN7SL698P, are not considered therapeutic targets; they lack protein or catalytic activity and are typically non-functional[3][5]. - 7SL pseudogenes can sometimes be transcribed and may, by analogy to other pseudogenes, exert rare regulatory effects (e.g., competing endogenous RNA activity or miRNA sponge functions), but there is no published evidence of this for RN7SL698P specifically[2]. - No drugs, disease associations, safety concerns, or biomarker use are reported for this pseudogene or similar 7SL-derived pseudogenes. Summary of interpretation: - This is **not** a therapeutic target or functional receptor/protein. - There is no druggability, mechanism of action, nor biomarker or disease relevance of note. - The entry appears to be correct for a processed pseudogene but incorrect as a drug discovery or therapeutic target.

Other names

RN7SL698PRNA, 7SL, cytoplasmic 698, pseudogene