7SL RNA 140 pseudogene, cytoplasmic (RN7SL140P)

RN7SL140P is a pseudogene derived from the 7SL RNA gene family, which encodes the RNA component of the signal recognition particle (SRP), involved in protein targeting to the endoplasmic reticulum[1][4][3]. As a pseudogene, RN7SL140P is a nonfunctional, truncated genomic sequence representing a copy of the functional 7SL RNA gene. The majority of 7SL-like sequences in the human genome are pseudogenes generated by the reverse transcription and insertion of 7SL RNA back into genomic DNA, often missing segments at the 5′ and/or 3′ ends[1][4]. While the canonical 7SL RNA is essential for SRP function and protein secretion, pseudogenes like RN7SL140P do not produce functional RNA and are generally considered to lack biological activity. However, research into pseudogenes has revealed that some may be transcribed and could have regulatory effects on gene expression, for instance by generating small RNAs or acting as miRNA decoys, but there is no evidence to date that RN7SL140P specifically has such a role[2]. RN7SL140P is not considered a therapeutic target, receptor, or enzyme, and its functional annotation is primarily as a noncoding, nonfunctional pseudogene. Key points: - RN7SL140P is a nonfunctional pseudogene, not a protein, enzyme, or receptor. - No known drugs, biomarkers, or therapeutic mechanisms linked to this locus. - The 7SL RNA gene family has many pseudogenes dispersed in the genome; most have no established function[1][4]. - Pseudogenes as a class may participate in regulatory pathways, but specific functions for RN7SL140P are not described in the literature[2]. Limitations/Concerns: - “RNA, 7SL, cytoplasmic 140, pseudogene” (RN7SL140P) is not a true therapeutic target or receptor, and should not be categorized as such. The “is_incorrect” flag is true for this context. - There is no evidence to suggest drug interaction or direct clinical relevance of this pseudogene.

Other names

RN7SL140PRNA, 7SL, cytoplasmic 140, pseudogene