Molecular Classification
Enzyme, Tyrosine kinase, Non-receptor tyrosine kinase, Proto-oncogene
Other Names
Tyrosine-protein kinase ABL1, c-Abl, v-Abl
Disease Roles
CancerChronic myeloid leukemiaLeukemia

ABL proto-oncogene 1 Overview

The ABL1 gene encodes a cytoplasmic and nuclear protein tyrosine kinase involved in numerous cellular processes, including cell division, cell differentiation, cell adhesion, and stress response. It is a proto-oncogene; mutations or chromosomal rearrangements, like the BCR-ABL fusion, can lead to cancerous transformation. The BCR–ABL fusion protein provides a molecular target for therapies such as imatinib used in CML treatment.

Mechanism of Action

Tyrosine kinase inhibitor

Biological Functions

Cell division
Cell differentiation
Cell adhesion
Stress response
DNA repair
Cell growth
Cell survival
Cell migration
Apoptosis
Regulation of actin dynamics
Homology Directed Repair
Infection signaling

Disease Associations

Cancer
Chronic myeloid leukemia
Leukemia
Congenital heart defects/skeletal malformations syndrome

Safety Considerations

  • Resistance to tyrosine kinase inhibitors
  • Off-target effects of kinase inhibitors

Interacting Drugs

Imatinib

Associated Biomarkers

Biomarker
BCR-ABL fusion gene
Philadelphia chromosome