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Target intelligence / Profile preview
ABL proto-oncogene 1 (ABL1)
- Target
- ABL1
- Molecular classification
- Enzyme, Tyrosine kinase, Non-receptor tyrosine kinase, Proto-oncogene
01
Overview
The ABL1 gene encodes a cytoplasmic and nuclear protein tyrosine kinase involved in numerous cellular processes, including cell division, cell differentiation, cell adhesion, and stress response. It is a proto-oncogene; mutations or chromosomal rearrangements, like the BCR-ABL fusion, can lead to cancerous transformation. The BCR–ABL fusion protein provides a molecular target for therapies such as imatinib used in CML treatment.
- Other names
- Tyrosine-protein kinase ABL1c-Ablv-Abl
02
Mechanism of action
Tyrosine kinase inhibitor
03
Biological functions
Cell divisionCell differentiationCell adhesionStress responseDNA repairCell growthCell survivalCell migrationApoptosisRegulation of actin dynamicsHomology Directed RepairInfection signaling
04
Disease associations
CancerChronic myeloid leukemiaLeukemiaCongenital heart defects/skeletal malformations syndrome
05
Safety considerations
Resistance to tyrosine kinase inhibitorsOff-target effects of kinase inhibitors
06
Interacting drugs
07
Biomarkers
BCR-ABL fusion genePhiladelphia chromosome
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