Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
ABL proto-oncogene 1, non-receptor tyrosine kinase (ABL1)
- Target
- ABL1
- Molecular classification
- Non-receptor tyrosine kinase, Enzyme, Proto-oncogene
01
Overview
ABL1 is a non-receptor tyrosine kinase involved in various cellular processes, including cell division, adhesion, differentiation, migration, DNA repair, and stress response. It is a proto-oncogene that, when mutated or aberrantly activated (e.g., through the BCR-ABL fusion in CML), can drive cancer development. Its activity is regulated by autoinhibitory interactions, and it localizes to both the cytoplasm and nucleus, participating in DNA repair and apoptosis. ABL1 phosphorylates numerous substrates, regulates actin cytoskeleton dynamics, and plays roles in lymphocyte signaling, synapse formation, and bacterial adhesion.
- Other names
- c-ABLv-abl Abelson murine leukemia viral oncogene homolog 1Abelson tyrosine-protein kinasep150
02
Mechanism of action
Tyrosine kinase inhibitor
03
Biological functions
Cell divisionCell adhesionCell differentiationCell migrationDNA repairApoptosisActin cytoskeleton regulationAntigen receptor signalingSynapse formation
04
Disease associations
CancerChronic Myeloid Leukemia (CML)Congenital heart defectsSkeletal malformations syndromeLeukemiaSolid tumors
05
Safety considerations
Resistance to tyrosine kinase inhibitorsOff-target effects
06
Biomarkers
BCR-ABL fusion gene (Philadelphia chromosome)
Beyond the preview
Go deeper on ABL proto-oncogene 1, non-receptor tyrosine kinase (ABL1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on ABL proto-oncogene 1, non-receptor tyrosine kinase (ABL1).