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Target intelligence / Profile preview
ABL proto-oncogene 2, non-receptor tyrosine kinase (ABL2)
- Target
- ABL2
- Molecular classification
- Enzyme, Protein Kinase, Non-receptor tyrosine kinase
01
Overview
ABL2, also known as ARG (Abelson-related gene), is a non-receptor tyrosine-protein kinase encoded by the *ABL2* gene. It belongs to the ABL family of tyrosine kinases. The protein plays critical roles in cell morphogenesis, motility, growth, and survival. Many of its biological functions overlap with those of ABL1. Constitutive activation or fusion events involving *ABL* family genes are implicated in leukemias. Dasatinib is a clinically used inhibitor targeting both BCR–ABL1 fusion proteins as well as wild-type ARG/ABL kinases.
- Other names
- ARGAbelson-related gene
02
Mechanism of action
Tyrosine kinase inhibitor
03
Biological functions
Cell morphogenesisCell motilityCell growthCell survivalRegulation of actin cytoskeletonSignal transduction
04
Disease associations
LeukemiaAcute lymphoblastic leukemia (ALL)Acute myeloid leukemia (AML)Cancer
05
Interacting drugs
Dasatinib
06
Biomarkers
Expression levels in KRAS mutant non-small cell lung cancer
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