Gosset Molecular Classification
Enzyme, Tyrosine Kinase, Non-receptor tyrosine kinase, Proto-oncogene
Other Names
c-ABL, Abelson tyrosine-protein kinase 1
Disease Roles
ABL1 Tyrosine-Protein Kinase Overview
ABL1 is a non-receptor tyrosine kinase that plays a crucial role in various cellular processes, including cell proliferation, differentiation, adhesion, and stress response. It is involved in DNA repair and apoptosis, particularly in response to DNA damage and oxidative stress. The ABL1 gene is a proto-oncogene, and mutations or translocations involving this gene, such as the BCR-ABL1 fusion, can lead to cancer.
Mechanism of Action
Tyrosine kinase inhibition
Biological Functions
Cell Proliferation
Cell Differentiation
Cell Adhesion
DNA Repair
Apoptosis
Stress response
Regulation of actin cytoskeleton
Disease Associations
Cancer
Chronic Myeloid Leukemia (CML)
Acute Lymphoblastic Leukemia (ALL)
Infection
Safety Considerations
- Resistance to tyrosine kinase inhibitors
- Off-target effects of TKIs
Interacting Drugs
Imatinib
Associated Biomarkers
| Biomarker |
|---|
| BCR-ABL1 fusion gene |