Acetyl-CoA Carboxylase 1 (ACC1)

Acetyl-CoA carboxylase 1 (ACC1) is a cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA. This reaction is the first and rate-limiting step in de novo fatty acid biosynthesis. ACC1 is a biotin-dependent enzyme and plays a central role in lipid metabolism by providing malonyl-CoA, which serves as both a substrate for fatty acid synthesis and an inhibitor of fatty acid oxidation. Altered expression or activity of ACC1 has been implicated in metabolic diseases such as obesity and diabetes, and overexpression can contribute to tumorigenesis making it an attractive target for cancer therapy research.

Other names

ACACAACACACCαAcetyl-Coenzyme A carboxylase alpha

Inhibition of ACC1 leads to decreased malonyl-CoA levels, reducing fatty acid synthesis and increasing fatty acid oxidation.