Target intelligence / Profile preview

Acetyl-CoA Synthetase (ACS)

Target: ACS
Molecular classification: Enzyme, Ligase

Overview

Acetyl-CoA synthetase (ACS), also known as acetate—CoA ligase, is an enzyme that catalyzes the activation of acetate by converting it into acetyl-CoA, a central metabolite in cellular metabolism. This reaction is crucial for integrating acetate into various metabolic pathways, including energy production and biosynthesis. ACS plays an indispensable role at multiple nodes within cellular metabolism across all domains of life.

Other names: Acetate—CoA ligase

Mechanism of action

Catalyzes the formation of acetyl-CoA from acetate, ATP, and CoA

Biological functions

Metabolite activationEnergy generationBiosynthesisRegulation of gene expression through histone acetylation

Disease associations

CancerMetabolic disorders

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