Gosset Molecular Classification
Enzyme, Ligase
Other Names
Acetate—CoA ligase
Disease Roles
Acetyl-CoA Synthetase Overview
Acetyl-CoA synthetase (ACS), also known as acetate—CoA ligase, is an enzyme that catalyzes the activation of acetate by converting it into acetyl-CoA, a central metabolite in cellular metabolism. This reaction is crucial for integrating acetate into various metabolic pathways, including energy production and biosynthesis. ACS plays an indispensable role at multiple nodes within cellular metabolism across all domains of life.
Mechanism of Action
Catalyzes the formation of acetyl-CoA from acetate, ATP, and CoA
Biological Functions
Metabolite activation
Energy generation
Biosynthesis
Regulation of gene expression through histone acetylation
Disease Associations
Cancer
Metabolic disorders
Safety Considerations
No safety concerns listed