Molecular Classification
Enzyme, Ligase
Other Names
ACAS2, ACS, ACSA, dJ1161H23.1, acyl-CoA synthetase short chain family member 2, Acetyl-Coenzyme A Synthetase 2, Acetyl-Coenzyme A Synthetase Cytoplasmic, ACECS1
Disease Roles
CancerMetabolic diseasesFatty liver disease

Acetyl-CoA synthetase 2 Overview

Acetyl-CoA synthetase 2 (ACSS2) is a cytosolic and nuclear enzyme that catalyzes the conversion of acetate into acetyl-coenzyme A (acetyl-CoA). This reaction is crucial for lipid synthesis, energy generation, and protein/histone acetylation. ACSS2 is highly expressed in liver, kidney, heart, and is also present in brain and testis. It plays a key role in cancer cell survival under metabolic stress and is a potential therapeutic target for cancer and metabolic diseases.

Mechanism of Action

Inhibition of acetyl-CoA production from acetate

Biological Functions

Lipid synthesis
Energy generation
Protein/histone acetylation
Regulation of lipid metabolism

Disease Associations

Cancer
Metabolic diseases
Fatty liver disease
Obesity

Safety Considerations

  • Potential for off-target effects
  • Blood-brain barrier penetration challenges for brain tumors

Interacting Drugs

MTB-9655