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Acetyl-coenzyme A synthetase, cytoplasmic (ACSS2)
- Target
- ACSS2
- Molecular classification
- Enzyme, Acyl-CoA synthetase, Short-chain family member
01
Overview
Acetyl-coenzyme A synthetase, cytoplasmic (ACSS2), is an enzyme that catalyzes the conversion of acetate into acetyl-CoA using ATP and CoA. This reaction is crucial for lipid synthesis, energy generation, and regulation of gene expression through histone acetylation. It is overexpressed in various cancers, promoting tumor growth and metastasis.
- Other names
- Acetate--CoA ligaseAcetyl-CoA synthetase (ACS; AceCS)Acetyl-Coenzyme A Synthetase 1/2AceCS1/ACECS1Acyl-CoA synthetase short-chain family member 2Acyl-activating enzyme
02
Mechanism of action
Inhibition of acetyl-CoA production from acetate
03
Biological functions
Lipid biosynthesisEnergy productionHistone acetylationMetabolic regulation
04
Disease associations
CancerGlioblastomaBreast cancerLiver cancerProstate cancerBladder cancerRenal cancer
05
Safety considerations
Potential impact on lipid metabolismPotential impact on histone acetylation
06
Biomarkers
ACSS2 expression level
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