Gosset Molecular Classification
Enzyme, Acyl-CoA synthetase, Short-chain family member
Other Names
Acetate--CoA ligase, Acetyl-CoA synthetase (ACS; AceCS), Acetyl-Coenzyme A Synthetase 1/2, AceCS1/ACECS1, Acyl-CoA synthetase short-chain family member 2, Acyl-activating enzyme
Disease Roles
Acetyl-coenzyme A synthetase, cytoplasmic Overview
Acetyl-coenzyme A synthetase, cytoplasmic (ACSS2), is an enzyme that catalyzes the conversion of acetate into acetyl-CoA using ATP and CoA. This reaction is crucial for lipid synthesis, energy generation, and regulation of gene expression through histone acetylation. It is overexpressed in various cancers, promoting tumor growth and metastasis.
Mechanism of Action
Inhibition of acetyl-CoA production from acetate
Biological Functions
Lipid biosynthesis
Energy production
Histone acetylation
Metabolic regulation
Disease Associations
Cancer
Glioblastoma
Breast cancer
Liver cancer
Prostate cancer
Bladder cancer
Renal cancer
Safety Considerations
- Potential impact on lipid metabolism
- Potential impact on histone acetylation
Associated Biomarkers
| Biomarker |
|---|
| ACSS2 expression level |