Gosset Molecular Classification
Receptor, Ligand-gated ion channel (Nicotinic), G protein-coupled receptor (Muscarinic)
Other Names
Cholinergic receptor
Disease Roles
Acetylcholine Receptor Overview
The acetylcholine receptor (AChR), also known as a cholinergic receptor, is an integral membrane protein that responds to the neurotransmitter acetylcholine. These receptors are essential for transmitting signals across synapses in both the central and peripheral nervous systems, mediating muscle contraction, autonomic nervous system responses, and various brain functions including memory and learning.
Mechanism of Action
Agonist or antagonist binding to acetylcholine receptors, modulating ion channel activity (nicotinic) or G-protein signaling (muscarinic).
Biological Functions
Signal transduction
Neuromuscular transmission
Autonomic nervous system signaling
Cognitive processes (memory and learning)
Disease Associations
Myasthenia gravis
Neurodegenerative disease
Cognitive disorders
Safety Considerations
- Side effects associated with cholinergic agonists (e.g., bradycardia, increased secretions)
- Side effects associated with cholinergic antagonists (e.g., dry mouth, blurred vision)
Interacting Drugs
Acetylcholine
Nicotine
Muscarine
Tubocurarine
Atropine