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Acetylcholine Receptor, Nematode Type B (None)
- Target
- None
- Molecular classification
- Nicotinic acetylcholine receptors (nAChRs), Cys-loop ligand-gated ion channel superfamily, Ligand-gated ion channel, Receptor
01
Overview
The B-type acetylcholine receptor (AChR) in nematodes is a subtype of nicotinic acetylcholine receptors (nAChRs), which are pentameric ligand-gated ion channels mediating excitatory neurotransmission at the neuromuscular junctions of nematodes. These receptors are critical for body movement and serve as major pharmacological targets for several classes of anthelmintic drugs. It is preferentially activated by bephenium.
- Other names
- B-type AChRNematode B-type acetylcholine receptorBephenium-sensitive acetylcholine receptor
02
Mechanism of action
Activation of the receptor leads to ion channel opening, depolarization, and muscle contraction. Anthelmintics act as agonists or antagonists, disrupting normal neuromuscular function and causing paralysis or death of the nematode.
03
Biological functions
Excitatory neurotransmissionMuscle contractionNeuromuscular junction signalingIon channel activitySignal transduction
04
Disease associations
Parasitic worm infection
05
Safety considerations
Potential for off-target effects on other cholinergic systemsDevelopment of drug resistance in nematodes
06
Interacting drugs
Bephenium
2 more in the full profile.
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