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Target intelligence / Profile preview
Acetylcholine Receptor (Neuromuscular Junction) (AChR)
- Target
- AChR
- Molecular classification
- Receptor, Ligand-gated ion channel, Ion channel
01
Overview
The acetylcholine receptor (AChR) at the neuromuscular junction is a neurotransmitter-gated ion channel that converts chemical signals from motor neurons into electrical signals in muscle fibers, leading to muscle contraction. It is a heteropentameric receptor composed of α, β, δ, and either γ (fetal) or ε (adult) subunits. Upon binding acetylcholine, the receptor opens its central pore, allowing cations to flow through and depolarize the muscle membrane. It is the primary target for neuromuscular blocking agents and is implicated in diseases like Myasthenia Gravis.
- Other names
- Nicotinic Acetylcholine Receptor (nAChR)Muscle-type nAChRNeuromuscular Junction AChR
02
Mechanism of action
Ligand-gated ion channel activation leading to Na+, K+, and Ca2+ influx and muscle cell depolarization.
03
Biological functions
NeurotransmissionMuscle contractionSignal transduction
04
Disease associations
Myasthenia Gravis
05
Safety considerations
ParalysisRespiratory failureSensitivity to neuromuscular blocking agentsAutoimmune response (Myasthenia Gravis)
06
Interacting drugs
Neuromuscular blocking agents (e.g., curare)
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